Analysis Tools
homeostasis/metabolism
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• unlike wild-type mice fed a high fat diet, similarly treated wild-type mice fail to exhibit hyperleptinemia
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• when fed a high fat diet
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• when fed standard chow or a high fat diet
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• during the light phase when fed standard chow
• during the dark phase when fed a high fat diet
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• unlike in wild-type mice, glucose oxidation and glucose conversion into lipids is not stimulated by Ang II with or without angiotensin II receptor, type 1a, antagonists
• when fed a high fat diet, glucose clearance is increased compared to in similarly treated wild-type mice
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• unlike wild-type mice fed a high fat diet, mice fail to exhibit an increase in plasma insulin levels
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• when fed standard chow or a high fat diet
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• lipid oxidation is increased 30% compared to in wild-type mice
• when fed a high fat diet, mice exhibit increased lipid oxidation compared to in similarly treated wild-type mice
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• when fed a high fat diet, mice fail to exhibit as much of an increase in muscle triglyceride content as in similarly treated wild-type mice
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• at 113 or 118 mm Hg equivalent renal perfusion pressure, diuresis and natriuresis are 3 times lower than in wild-type mice
• as renal perfusion pressure increases, fractional sodium and water excretion curves are shifted rightward compared to in wild-type mice
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• at 113 or 118 mm Hg equivalent renal perfusion pressure, natriuresis is 3 times lower than in wild-type mice
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• unlike in wild-type mice, glucose oxidation and glucose conversion into lipids is not stimulated by Ang II with or without angiotensin II receptor, type 1a, antagonists
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• L-NAME-treated mice exhibit a greater increase in blood pressure and reduced heart rate variability compared with similarly treated wild-type mice
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muscle
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• when fed a high fat diet, mice fail to exhibit as much of an increase in muscle triglyceride content as in similarly treated wild-type mice
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nervous system
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• the number of cells in the medial habenula is increased compared to in wild-type mice
• however, the size of the neuronal somata is normal
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• the number of cells in the ventromedial, ventroposterior, and anterodorsal nuclei and zona incerta is increased compared to in wild-type mice
• however, the size of the neuronal somata is normal
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• the number of cells in the basolateral complex, lateral complex, basolateral nucleus, medial nucleus, central nucleus, and basomedial nucleus of the amygdala is increased compared to in wild-type mice
• however, the size of the neuronal somata is normal
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• the number of cells in the CA1 region is increased than in wild-type mice
• however, the size of the neuronal somata is normal
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• the number of cells in the CA2 region is increased than in wild-type mice
• however, the size of the neuronal somata is normal
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• the number of cells in the CA3 region is increased than in wild-type mice
• however, the size of the neuronal somata is normal
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• the density and number of cells in the piriform cortex is increased than in wild-type mice
• however, the size of the neuronal somata is normal
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• systolic blood pressure variability in the low frequency band is reduced compared to in wild-type mice
• baroreflex sensitivity calculated as the mean value of the transfer function between systolic blood pressure and RR intervals in the low frequency band or with the sequence technique for upslopes of systolic blood pressure is increased compared to in wild-type mice
• mice exhibit higher baroreflex sensitivity compared with wild-type mice
• however, hypertension-producing treatments do not affect baroreflex sensitivity
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renal/urinary system
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• cortical blood flow is lower than in wild-type mice
• at high renal perfusion pressure, renal blood flow is lower than in similarly treated wild-type mice
• as renal perfusion pressure increases, mice fail to exhibit an increase in medullary blood flow unlike in similarly treated wild-type mice
• however, glomerular filtration rate is normal
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• renal vascular resistance is higher than in wild-type mice
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• following unilateral ureter obstruction, tubulointerstitial apoptosis is decreased compared to in similarly treated wild-type mice
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• at 113 or 118 mm Hg equivalent renal perfusion pressure, diuresis and natriuresis are 3 times lower than in wild-type mice
• as renal perfusion pressure increases, fractional sodium and water excretion curves are shifted rightward compared to in wild-type mice
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• at 113 or 118 mm Hg equivalent renal perfusion pressure, natriuresis is 3 times lower than in wild-type mice
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• following unilateral ureter obstruction, mice exhibit increased fibrosis, widening of interstitial space, increased in cellularity and loss of close contact between peritubular capillaries and tubules with increased intervening trichrome+ materials compared with similarly treated wild-type mice
• however, unobstructed kidneys are normal
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• following unilateral ureter obstruction, interstitial collagen is increased compared to in similarly treated wild-type mice
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cardiovascular system
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• following transplantation of LL2 carcinoma cells, mice exhibit a decrease in angiogenesis compared with similarly treated wild-type mice
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• following transplantation of LL2 carcinoma cells, mice treated with the ACE inhibitor enalapril exhibit a decrease in angiogenesis compared with wild-type mice transplantated with LL2 carcinoma cells
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• cortical blood flow is lower than in wild-type mice
• at high renal perfusion pressure, renal blood flow is lower than in similarly treated wild-type mice
• as renal perfusion pressure increases, mice fail to exhibit an increase in medullary blood flow unlike in similarly treated wild-type mice
• however, glomerular filtration rate is normal
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• renal vascular resistance is higher than in wild-type mice
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• unlike wild-type mice fed a high fat diet, similarly treated mutant mice fail to exhibit an increase in systolic blood pressure
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• L-NAME-treated mice exhibit a greater increase in blood pressure compared with similarly treated wild-type mice
• mice on a DOCA-salt regime exhibit a greater increase in blood pressure compared with similarly treated wild-type mice
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• in L-NAME and DOCA-salt treated mice
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adipose tissue
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• 2-fold lower in epididymal adipose tissue compared to in wild-type mice
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• 2-fold lower in epididymal adipose tissue compared to in wild-type mice
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• unlike wild-type mice fed a high fat diet, similarly treated wild-type mice fail to exhibit an increase in epididymal adipose tissue
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behavior/neurological
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• when fed a high fat diet
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growth/size/body
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• when fed a high fat diet
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• when fed standard chow or a high fat diet
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cellular
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• following unilateral ureter obstruction, tubulointerstitial apoptosis is decreased compared to in similarly treated wild-type mice
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