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Phenotypes Associated with This Genotype
Genotype
MGI:4453797
Allelic
Composition
Hba-a1tm1Ywk/Hbath-J
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba-a1tm1Ywk mutation (0 available); any Hba-a1 mutation (1 available)
Hbath-J mutation (2 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants do not survive as newborns

growth/size/body
• at E19.5, mutant fetuses are smaller than control fetuses

hematopoietic system
• at E17.5, mutant fetuses display severe hemolytic anemia
• at E17.5, mutant erythrocytees display notable anisocytosis, poikilocytosis, polychromasia, and targeting, characteristic of severe thalassemia
• virtually all mutant erythrocytes exhibit hemoglobin H inclusions
• at E17.5, hemoglobin H (beta4) is the major component constituting 55%-65% of total hemoglobin, as shown by isoelectric focusing electrophoresis
• at E17.5, mutant fetuses exhibit very high reticulocyte counts

integument
• at E19.5, mutant fetuses are paler than control fetuses

Mouse Models of Human Disease
OMIM ID Ref(s)
Hemoglobin--Alpha Locus 1; HBA1 141800 J:35018


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory