Mouse Genome Informatics
cx
    Hba-a1tm1Ywk/Hbath-J
involves: 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mutants do not survive as newborns

growth/size/body
• at E19.5, mutant fetuses are smaller than control fetuses

hematopoietic system
• at E17.5, mutant erythrocytees display notable anisocytosis, poikilocytosis, polychromasia, and targeting, characteristic of severe thalassemia
• virtually all mutant erythrocytes exhibit hemoglobin H inclusions
• at E17.5, hemoglobin H (beta4) is the major component constituting 55%-65% of total hemoglobin, as shown by isoelectric focusing electrophoresis
• at E17.5, mutant fetuses exhibit very high reticulocyte counts
• at E17.5, mutant fetuses display severe hemolytic anemia

integument
• at E19.5, mutant fetuses are paler than control fetuses

Mouse Models of Human Disease
OMIM IDRef(s)
Hemoglobin--Alpha Locus 1; HBA1 141800 J:35018