About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4452376
Allelic
Composition
Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Ightm4.1Mnz
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (58 available)
Ightm3Mnz mutation (1 available); any Igh mutation (41 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (41 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (98 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells

immune system
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory