Phenotypes Associated with This Genotype

Genotype
MGI:4443107

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Trp53*,-EGFP)Medz}/Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:158953 )

N • hematopoietic stem and progenitor cells (HSPCs) of mice treated with tamoxifen do not exhibit a selective advantage over cells not expressing the modified cDNA

N • the total number of HSPCs is normal in irradiated mice

abnormal hematopoietic system physiology ( J:158953 )

• following irradiation, the proportion of GFP+ cells in the hematopoietic stem and progenitor cell compartment and myeloid and lymphoid lineages of tamoxifen-treated mice is increased compared to un-irradiated mice

• GFP+ cell accumulation occurs whether mice are treated with tamoxifen 2 or 7 days after irradiation

• however, no competitive advantage is observed when mice are treated with tamoxifen and 5-fluorouracil without DNA damage or over similarly treated Cdkn2a^tm2.1Rdp cells in irradiated chimera experiments