Phenotypes Associated with This Genotype

Genotype
MGI:4443070

• Allelic Composition: Itga2b^tm1Tlr/Itga2b⁺
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal platelet physiology ( J:63961 )

• unlike platelet-rich plasma (PRP) from wild-type controls which complete the retraction of opaque thrombin-induced clots within a 2-hr period, heterozygous PRP shows both a delayed and incomplete clot retraction during this period

abnormal platelet activation ( J:63961 )

• heterozygous platelets display a specific fibrinogen binding capacity of 57% relative to 100% in wild-type platelets

abnormal platelet aggregation ( J:63961 )

• although heterozygous platelets exhibit substantial aggregation in response to ADP or collagen, the collagen response is significantly delayed relative to that in wild-type controls

hematopoietic system

abnormal platelet physiology ( J:63961 )

• unlike platelet-rich plasma (PRP) from wild-type controls which complete the retraction of opaque thrombin-induced clots within a 2-hr period, heterozygous PRP shows both a delayed and incomplete clot retraction during this period

abnormal platelet activation ( J:63961 )

• heterozygous platelets display a specific fibrinogen binding capacity of 57% relative to 100% in wild-type platelets

abnormal platelet aggregation ( J:63961 )

• although heterozygous platelets exhibit substantial aggregation in response to ADP or collagen, the collagen response is significantly delayed relative to that in wild-type controls