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Phenotypes Associated with This Genotype
Genotype
MGI:4442801
Allelic
Composition		 Atmtm1Pmc/Atmtm1Pmc
Trp73tm2Mak/Trp73tm2Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Pmc mutation (0 available); any Atm mutation (168 available)
Trp73tm2Mak mutation (3 available); any Trp73 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants

immune system
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants

cellular
decreased cellular sensitivity to gamma-irradiation ( J:157905 )
• the increased thymocyte apoptosis in response to gamma-irradiation is reversed compared to mice homozygous for Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants

homeostasis/metabolism
decreased cellular sensitivity to gamma-irradiation ( J:157905 )
• the increased thymocyte apoptosis in response to gamma-irradiation is reversed compared to mice homozygous for Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory