Phenotypes Associated with This Genotype

Genotype
MGI:4442505

• Allelic Composition: Fbln5^tm1.1Hiya/Fbln5^tm1.1Hiya
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased angiogenesis ( J:159246 )

• tumors from pancreatic carcinoma cell line Pan02 injected subcutaneously exhibit reduced angiogenesis compared with tumors from cells injected into wild-type mice

• however, treatment with antioxidant rescues tumor angiogenesis

neoplasm

decreased tumor growth/size ( J:159246 )

• tumors from pancreatic carcinoma cell line Pan02 injected subcutaneously exhibit reduced size, growth, and angiogenesis and increased reactive oxygen species compared with tumors from cells injected into wild-type mice

• however, treatment with antioxidant rescues tumor angiogenesis and growth