Phenotypes Associated with This Genotype

Genotype
MGI:4442469

• Allelic Composition: Pax3^tm2Joe/Pax3^tm2Joe; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:159124 )

• mutant die immediately after birth

growth/size/body

decreased birth body size ( J:159124 )

• smaller than wild-type littermates at birth

homeostasis/metabolism

cyanosis ( J:159124 )

• cyanotic at birth

muscle

hypaxial muscle hypoplasia ( J:159124 )

• poorly developed limb and diaphragm musculature at birth

• skeletal muscle is severely deficient in the limbs

• severe deficiency of forelimb musculature

respiratory system

respiratory failure ( J:159124 )

• newborns fail to initiate respirations

embryo

spina bifida ( J:159124 )

• occasional mild spina bifida are seen at birth

cardiovascular system

cardiovascular system phenotype ( J:159124 )

N • normal septation of the aorta and pulmonary artery

nervous system

spina bifida ( J:159124 )

• occasional mild spina bifida are seen at birth