Phenotypes Associated with This Genotype

Genotype
MGI:4442429

• Allelic Composition: Tg(Cd4-Il17rb)#Cdon/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:158594 )

• IL25 treatment induces more IL5 positive cells and fewer IFNG expressing cells

increased eosinophil cell number ( J:158594 )

• in the bronchoalveolar lavage of mice after repeated challenge with allergens

increased susceptibility to type I hypersensitivity reaction ( J:158594 )

• more cells in the bronchoalveolar lavage, predominantly eosinophils and CD4+ T cells, after repeated intranasal challenge with the Aspergillus oryzae protease and OVA allergens

decreased interferon-gamma secretion ( J:158594 )

• in cultured naive T cells after activation with anti-CD3 and anti CD28 in the presence of IL25

increased interleukin-13 secretion ( J:158594 )

• in splenocytes, lung cells and draining lymph node cells after repeated intranasal challenge with the Aspergillus oryzae protease and OVA allergens

increased interleukin-5 secretion ( J:158594 )

• in cultured naive T cells after activation with anti-CD3 and anti CD28 in the presence of IL25

• in splenocytes, lung cells and draining lymph node cells after repeated intranasal challenge with the Aspergillus oryzae protease and OVA allergens, and OVA challenge ex vivo

increased interleukin-9 secretion ( J:158594 )

• a strong induction of IL9 expression in T cells treated with IL25

lung inflammation ( J:158594 )

• more cells in the bronchoalveolar lavage, predominantly eosinophils and CD4+ T cells, after repeated intranasal challenge with the Aspergillus oryzae protease and OVA allergens

respiratory system

lung inflammation ( J:158594 )

• more cells in the bronchoalveolar lavage, predominantly eosinophils and CD4+ T cells, after repeated intranasal challenge with the Aspergillus oryzae protease and OVA allergens

hematopoietic system

hematopoietic system phenotype ( J:158594 )

N • naive mice have no defect in overall development of hematopoietic system

abnormal T cell differentiation ( J:158594 )

• IL25 treatment induces more IL5 positive cells and fewer IFNG expressing cells

increased eosinophil cell number ( J:158594 )

• in the bronchoalveolar lavage of mice after repeated challenge with allergens