Analysis Tools
muscle
|
• some tendon fibers connecting forearm muscles to skeletal elements in the handplate are thinner than in controls and some have fused together
• in forelimb, tendons develop functional entheses on the forming skeleton
|
limbs/digits/tail
|
• with tamoxifen treatment at E9.5, limbs display minor skeletal deformities similar to those in humans with Holt-Oram syndrome (triphalangeal thumb)
• muscle patterning is disrupted similarly to that with tamoxifen treatment at E10.5
• patterning of tendon fibers connecting forearm muscles to skeletal elements in the handplate is significantly disrupted compared to wild-type; fewer tendon fibers are present
• mispatterned muscles make functional myotendinous attachments to tendons
|
skeleton
|
• some tendon fibers connecting forearm muscles to skeletal elements in the handplate are thinner than in controls and some have fused together
• in forelimb, tendons develop functional entheses on the forming skeleton
|
