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Phenotypes Associated with This Genotype
Genotype
MGI:4441392
Allelic
Composition		 Prox1tm4.1Gco/Prox1tm4.1Gco
Genetic
Background		 involves: 129S1/Sv * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prox1tm4.1Gco mutation (0 available); any Prox1 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
edema ( J:158959 )
• severe edema is observed at E13.5

immune system
decreased lymphatic vessel endothelial cell number ( J:158959 )
• at level of jugular lymph sacs, reduction in number of lymphatic endothelial cells (LECs) is detected compared to heterozygous controls
• along anteroposterior axis of embryo, only a few Prox1+ve LECs that have abnormally aggregated around the jugular vein are detected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory