Mouse Genome Informatics
cn
    Fli1tm1Matr/Fli1tm1Matr
Tg(Tek-cre)12Flv/0

B6.Cg-Fli1tm1Matr Tg(Tek-cre)12Flv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• dermal vasculature is disorganized with irregular vessel diameters unlike in wild-type mice
• dermal capillaries, arterioles, and venules exhibit increased vessel diameter compared to in wild-type mice
• dermal capillaries, arterioles, and venules exhibit increased vessel diameter compared to in wild-type mice
• arterioles exhibit a 65% increase in endothelial cells and pericytes compared to in wild-type mice
• arterioles exhibit a 65% increase in endothelial cells and pericytes compared to in wild-type mice
• however, endothelial cell proliferation or apoptosis rates are normal
• capillaries are dilated in the skin vascular network compared to in wild-type mice
• dermal capillaries, arterioles, and venules exhibit increased vessel diameter compared to in wild-type mice
• arterioles exhibit a 65% increase in endothelial cells and pericytes compared to in wild-type mice
• pericyte/vascular smooth muscle cell coverage is decreased compared to in wild-type mice
• pericyte/vascular smooth muscle cell coverage is decreased compared to in wild-type mice
• dermal capillaries, arterioles, and venules exhibit increased vessel diameter compared to in wild-type mice
• in arterioles of dermal vascular networks
• microaneurysms are observed in the skin vascular network compared with wild-type mice
• mice are more hemorrhagic against mechanical force such as cervical dislocation and surgical procedure compared with similarly treated wild-type mice
• skin vasculature on the ears and back exhibits increased permeability compared with wild-type mice
• skin vascular leakage is more severe when ears are treated with mineral oil compared with wild-type ears treated with mustard oil

growth/size
• from P3 until 3 months of age

muscle
• pericyte/vascular smooth muscle cell coverage is decreased compared to in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Scleroderma, Familial Progressive 181750 J:158658