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Phenotypes Associated with This Genotype
Genotype
MGI:4441385
Allelic
Composition
Fli1tm1Matr/Fli1tm1Matr
Tg(Tek-cre)12Flv/0
Genetic
Background
B6.Cg-Fli1tm1Matr Tg(Tek-cre)12Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Matr mutation (0 available); any Fli1 mutation (15 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• dermal vasculature is disorganized with irregular vessel diameters unlike in wild-type mice
• dermal capillaries, arterioles, and venules exhibit increased vessel diameter compared to in wild-type mice
• dermal capillaries, arterioles, and venules exhibit increased vessel diameter compared to in wild-type mice
• arterioles exhibit a 65% increase in endothelial cells and pericytes compared to in wild-type mice
• arterioles exhibit a 65% increase in endothelial cells and pericytes compared to in wild-type mice
• however, endothelial cell proliferation or apoptosis rates are normal
• capillaries are dilated in the skin vascular network compared to in wild-type mice
• dermal capillaries, arterioles, and venules exhibit increased vessel diameter compared to in wild-type mice
• arterioles exhibit a 65% increase in endothelial cells and pericytes compared to in wild-type mice
• pericyte/vascular smooth muscle cell coverage is decreased compared to in wild-type mice
• pericyte/vascular smooth muscle cell coverage is decreased compared to in wild-type mice
• dermal capillaries, arterioles, and venules exhibit increased vessel diameter compared to in wild-type mice
• in arterioles of dermal vascular networks
• microaneurysms are observed in the skin vascular network compared with wild-type mice
• mice are more hemorrhagic against mechanical force such as cervical dislocation and surgical procedure compared with similarly treated wild-type mice
• skin vasculature on the ears and back exhibits increased permeability compared with wild-type mice
• skin vascular leakage is more severe when ears are treated with mineral oil compared with wild-type ears treated with mustard oil

growth/size/body
• from P3 until 3 months of age

muscle
• pericyte/vascular smooth muscle cell coverage is decreased compared to in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Scleroderma, Familial Progressive 181750 J:158658


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory