Phenotypes Associated with This Genotype

Genotype
MGI:4441378

• Allelic Composition: Gja1^tm1Kwi/Gja1^tm1Kwi; Tg(S100b-cre)20Ito/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:159160 )

N • cytoarchitecture of the adult brain appears normal; at 1.5 months, Bergmann glial processes show no morphologic abnormalites and Purkinje cell dendrite branching is normal

N • cerebellar LTD induction and maintenance is not affected; no loss of astrocytes in the cerebellar cortex are detected in mutants

abnormal glial cell physiology ( J:159160 )

• intercellular coupling of Bergmann glial cells (through gap junctions) as indicated by dye injection is significantly reduced compared to Gja1^tm1Kwi homozygous controls at 3.5 months

behavior/neurological

behavior/neurological phenotype ( J:159160 )

N • no enhanced locomotor activity or increased exploratory behavior is observed in open field tests

N • associative motor learning (in delay eyeblink conditioning) is similar between mutants and controls at 3-3.5 months

cellular

abnormal glial cell physiology ( J:159160 )

• intercellular coupling of Bergmann glial cells (through gap junctions) as indicated by dye injection is significantly reduced compared to Gja1^tm1Kwi homozygous controls at 3.5 months