Tg(S100b-cre)20Ito
Transgene Detail

Summary

• Symbol: Tg(S100b-cre)20Ito
• Name: transgene insertion 20, Shigeyoshi Itohara
• MGI ID: MGI:4441370
• Synonyms: S100b-Cre, Tg20
• Transgene: Tg(S100b-cre)20Ito Location: unknown
• Alliance: Tg(S100b-cre)20Ito page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(S100b-cre)20Ito expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	S100b

• Mutation details: The nls-cre (nuclear localization sequence-cre) polyA cassette was inserted immediately upstream of the translation initiation site in an 11.7 kb S100b promoter-containing genomic sequence (-5387/+6357). This targeting construct was microinjected into pronuclei of fertilized C57BL/6 embryos. Six lines were generated, four of which showed similar recombination patterns in the adult brain when crossed to transgenic reporter mice. Line 20 (Tg20) displayed no recombination in the heart, lung, kidney, spleen, skeletal muscle, and blood vessel and partial recombination in skin and liver. (J:159160)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	S100b (species not specified) Summary of all recombinase alleles driven by S100b. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:159160 Tanaka M, et al., Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning. Front Behav Neurosci. 2008;2:1
• All: 3 reference(s)