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Phenotypes Associated with This Genotype
Genotype
MGI:4441314
Allelic
Composition		 Adam22tm1.1Mejr/Adam22tm1.1Mejr
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam22tm1.1Mejr mutation (0 available); any Adam22 mutation (71 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron morphology ( J:158973 )
• mice exhibit promyelin arrested fibers unlike wild-type mice
abnormal myelination ( J:158973 )
• mice exhibit promyelin arrested fibers unlike wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory