Phenotypes Associated with This Genotype

Genotype
MGI:4441312

• Allelic Composition: Drd2^tm1Yyw/Drd2^tm1Yyw
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased aggression towards male mice ( J:103562 )

• unlike wild-type controls, resident male homozygotes display significantly reduced or absent offensive aggression towards wild-type A/J male intruders in the resident-intruder test

• at 6-7 months of age, most male homozygotes not only display a significantly reduced attack frequency and duration but show distinctly non-aggressive behaviors e.g. social grooming and peacefully keeping a short distance from the male intruder

• whereas old (15-18 months of age) and middle-aged (6-7 months of age) male homozygotes display a similar degree of offensive aggression, they both show significantly less aggression than young (2.5-4 months of age) male homozygotes

• young and middle-aged male homozygotes display significantly reduced offensive aggression relative to age-matched wild-type controls; however, no difference in aggression is observed between old homozygous mutant and wild-type males

• although an age-related reduction in offensive aggression is noted in both wild-type and mutant males, no significant differences in locomotor activity are observed between any two different age groups within the same genotype