Phenotypes Associated with This Genotype

Genotype
MGI:4441276

• Allelic Composition: Rev3l^tm1Rwd/Rev3l^tm2.1Rwd; Trp53^tm1Brd/Trp53⁺; Tg(MMTV-cre)1Mam/0
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:158922 )

• 11 of 36 mice develop mammary tumors consisting of solid carcinoma, carcinosarcoma, adenosquamous carcinoma, and osteosarcoma

• incidence of mammary tumors is increased while latency to development of tumors is decreased compared with Trp53^tm1Brd heterozygotes

increased carcinoma incidence ( J:158922 )

• in the mammary tissue of some mice

increased osteosarcoma incidence ( J:158922 )

• in the mammary tissue of one mouse

integument

increased mammary gland tumor incidence ( J:158922 )

• 11 of 36 mice develop mammary tumors consisting of solid carcinoma, carcinosarcoma, adenosquamous carcinoma, and osteosarcoma

• incidence of mammary tumors is increased while latency to development of tumors is decreased compared with Trp53^tm1Brd heterozygotes

skeleton

increased osteosarcoma incidence ( J:158922 )

• in the mammary tissue of one mouse

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:158922 )

• 11 of 36 mice develop mammary tumors consisting of solid carcinoma, carcinosarcoma, adenosquamous carcinoma, and osteosarcoma

• incidence of mammary tumors is increased while latency to development of tumors is decreased compared with Trp53^tm1Brd heterozygotes