Phenotypes for Runx1 Runx2 Tg(Prrx1-cre)1Cjt MGI:4440959 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Runx2^tm1Mjo/Runx2^tm1Mjo Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1.1Stkd mutation (0 available); any Runx1 mutation (34 available)
Runx2^tm1Mjo mutation (0 available); any Runx2 mutation (45 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:158761 )

• mice are non-viable

skeleton

absent sternum ( J:158761 )

• in newborn mice with no sign of sternal bar development

abnormal skeleton development ( J:158761 )

• sternal bar development is absent unlike in wild-type mice

abnormal chondrocyte differentiation ( J:158761 )

• at E13.5, reduced Alcian blue staining of cartilaginous matrices and marker expression compared to in wild-type mice indicate impaired chondrocyte differentiation

abnormal bone mineralization ( J:158761 )

• mice fail to exhibit mineralization of most skeletal elements, including the sternum, unlike in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/31/2026 MGI 6.24