Phenotypes Associated with This Genotype

Genotype
MGI:4440912

• Allelic Composition: Mef2c^tm1Jjs/Mef2c^tm1Jjs; Tg(Slc5a2-cre)1Tauc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased kidney cell proliferation ( J:158762 )

• cell proliferation in kidneys is elevated compared to in wild-type kidneys

kidney cortex cyst ( J:158762 )

• at 5 months, 9 of 12 mice exhibit small bilateral cysts with flat lining cells unlike wild-type mice

• mice exhibit small glomerular cysts unlike wild-type mice

dilated renal tubule ( J:158762 )

• in 9 of 12 mice at 5 months

dilated distal convoluted tubule ( J:158762 )

• in 9 of 12 mice at 5 months

dilated proximal convoluted tubule ( J:158762 )

• in 9 of 12 mice at 5 months

cellular

increased kidney cell proliferation ( J:158762 )

• cell proliferation in kidneys is elevated compared to in wild-type kidneys

growth/size/body

kidney cortex cyst ( J:158762 )

• at 5 months, 9 of 12 mice exhibit small bilateral cysts with flat lining cells unlike wild-type mice

• mice exhibit small glomerular cysts unlike wild-type mice