Phenotypes Associated with This Genotype

Genotype
MGI:4440837

• Allelic Composition: Uhrf1^tm1Hko/Uhrf1^tm1Hko
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:129097 )

• 100% lethality by E12.5

embryo

small pharyngeal arch ( J:129097 )

abnormal mesoderm development ( J:129097 )

• increased apoptosis in cephalic mesoderm at E9.5

embryonic growth arrest ( J:129097 )

• developmental arrest after gastrulation

embryonic growth retardation ( J:129097 )

• by E9.5

abnormal neural tube closure ( J:129097 )

abnormal allantois morphology ( J:129097 )

• failure of outgrowth of allantois

cellular

abnormal DNA methylation ( J:129097 )

• global CpG methylation is substantially reduced

nervous system

abnormal nervous system morphology ( J:129097 )

• increased apoptosis in the ventral region of the neurtaql tubre at E9.5

abnormal neural tube closure ( J:129097 )

craniofacial

small pharyngeal arch ( J:129097 )

skeleton

abnormal sclerotome morphology ( J:129097 )

• increased apoptosis at E9.5

growth/size/body

embryonic growth retardation ( J:129097 )

• by E9.5