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Phenotypes Associated with This Genotype
Genotype
MGI:4440461
Allelic
Composition
Cybbtm1Din/Y
Tg(SOD1*G93A)dl1Gur/0
Genetic
Background
B6.Cg-Cybbtm1Din Tg(SOD1*G93A)dl1Gur
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cybbtm1Din mutation (1 available); any Cybb mutation (27 available)
Tg(SOD1*G93A)dl1Gur mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• life span improved relative to mice only carrying Tg(SOD1*G93A)dl1Gur

behavior/neurological
• used as a measure of paralysis
• improved relative to mice only carrying Tg(SOD1*G93A)dl1Gur
• reached end stage paralysis later than mice only carrying Tg(SOD1*G93A)dl1Gur

nervous system
• improved relative to mice only carrying Tg(SOD1*G93A)dl1Gur
• 50% more anterior horn motor neurons in the anterior horn of the spinal cord than in mice only carrying Tg(SOD1*G93A)dl1Gur
• more myelinated axons in the 5th lumbar anterior roots than in mice only carrying Tg(SOD1*G93A)dl1Gur
• more innervated end plates than in mice only carrying Tg(SOD1*G93A)dl1Gur

muscle
• in the fibularis and peroneus longus

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 1 DOID:0060193 OMIM:105400
J:111782


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory