Mouse Genome Informatics
cx
    Cybbtm1Din/Y
Tg(SOD1*G93A)dl1Gur/0

B6.Cg-Cybbtm1Din Tg(SOD1*G93A)dl1Gur
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• life span improved relative to mice only carrying Tg(SOD1*G93A)dl1Gur (J:111782)

behavior/neurological
• used as a measure of paralysis (J:111782)
• improved relative to mice only carrying Tg(SOD1*G93A)dl1Gur (J:111782)
• reached end stage paralysis later than mice only carrying Tg(SOD1*G93A)dl1Gur (J:111782)

nervous system
• improved relative to mice only carrying Tg(SOD1*G93A)dl1Gur (J:111782)
• 50% more anterior horn motor neurons in the anterior horn of the spinal cord than in mice only carrying Tg(SOD1*G93A)dl1Gur (J:111782)
• more myelinated axons in the 5th lumbar anterior roots than in mice only carrying Tg(SOD1*G93A)dl1Gur (J:111782)
• more innervated end plates than in mice only carrying Tg(SOD1*G93A)dl1Gur (J:111782)

muscle
• in the fibularis and peroneus longus (J:111782)

Mouse Models of Human Disease
OMIM IDRef(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:111782