Phenotypes Associated with This Genotype

Genotype
MGI:4439313

• Allelic Composition: Igh^tm1Aak/Igh^tm1Aak
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:158402 )

• mice exhibit decreased B and pre-B cells and an increase in pro-B cells compared with wild-type mice indicating impaired B cell development

• however, V(D)J recombination is normal

increased pro-B cell number ( J:158402 )

• 3- to 5-fold in the bone marrow

decreased B cell number ( J:158402 )

• 4-fold decrease in B220+ cells in the bone marrow

• IgM+ B cells are virtually absent from the bone marrow

• 5-fold in the spleen

decreased pre-B cell number ( J:158402 )

• 2.5-fold in the bone marrow

hematopoietic system

abnormal B cell differentiation ( J:158402 )

• mice exhibit decreased B and pre-B cells and an increase in pro-B cells compared with wild-type mice indicating impaired B cell development

• however, V(D)J recombination is normal

increased pro-B cell number ( J:158402 )

• 3- to 5-fold in the bone marrow

decreased B cell number ( J:158402 )

• 4-fold decrease in B220+ cells in the bone marrow

• IgM+ B cells are virtually absent from the bone marrow

• 5-fold in the spleen

decreased pre-B cell number ( J:158402 )

• 2.5-fold in the bone marrow