Igh^tm1Aak
Targeted Allele Detail

Summary

• Symbol: Igh^tm1Aak
• Name: immunoglobulin heavy chain complex; targeted mutation 1, Ahmed Amine Khamlichi
• MGI ID: MGI:4439311
• Synonyms: Smu^delta, SmuN
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158402
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 4.6 kb of the Imu-Cmu intron was replaced with a floxed neo cassette in the sense orientation. Only 172 bp were left downstream of Imu exon and 75 bp upstream of the Cmu1 exon, including the donor and the acceptor splice sites. (J:90548, J:158402)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 43 strains or lines available

References

• Original: J:158402 Haddad D, et al., Replacement of Imu-Cmu intron by NeoR gene alters Imu germ-line expression but has no effect on V(D)J recombination. Mol Immunol. 2010 Feb;47(5):961-71
• All: 5 reference(s)