Analysis Tools
mortality/aging
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• at 16 weeks of age after 10 weeks on a western style diet only 52% of mice compared to 100% survival for diet matched Ldlr single mutants
• no increase in mortality is seen in mice kept on a standard chow diet
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• at 12 weeks of age after 6 weeks on a western style diet, survival is reduced to 38% for mice compared to 96% for diet matched Apoe single mutants
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• similar to that in Itgb3 single mutants
• only 62% survival to weaning for compared to 96% survival in mice null for Apoe alone
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immune system
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• isolated small foci of mononuclear cells are present in lung after 6 weeks of high-fat feeding
• in mice fed a high fat diet pneumonitis is the cause of death
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respiratory system
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• isolated small foci of mononuclear cells are present in lung after 6 weeks of high-fat feeding
• in mice fed a high fat diet pneumonitis is the cause of death
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hematopoietic system
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• western diet fed mice are anemic compared to diet matched mice null for Apoe alone
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growth/size/body
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• after 6 weeks on a western diet mice weighed less than diet matched Apoe single mutants
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homeostasis/metabolism
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• after 6 weeks on a western diet mice weighed less than diet matched Apoe single mutants
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cardiovascular system
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• on a western diet, lesions are 2.6 fold greater at the arch, 3.3 fold greater at the thoracic aorta, and 5.6-fold greater at the abdominal aorta compared to diet matched Apoe single mutants
• on chow diet at approximately 11 months of age, lesions are 2.4 fold greater at the arch, 3 fold greater at the thoracic aorta than in diet matched Apoe single mutants.
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