Phenotypes Associated with This Genotype

Genotype
MGI:4439082

• Allelic Composition: Itga6^tm2Egl/Itga6^tm2Egl; Tg(Tie1-cre)9Ref/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor vascularization ( J:156496 )

• injected cell derived tumors display increased blood vessel density

increased tumor growth/size ( J:156496 )

• increase in tumor size 10 - 12 days after injection of Lewis lung carcinoma or murine melanoma cells compared to controls

cardiovascular system

abnormal tumor vascularization ( J:156496 )

• injected cell derived tumors display increased blood vessel density

increased angiogenesis ( J:156496 )

• increase in vessel growth into implanted VEGF treated sponges and enhanced VEGF induced micro vessel sprouting in vitro compared to controls

• however, vessel density in untreated skin is not different from controls