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Phenotypes Associated with This Genotype
Genotype
MGI:4438921
Allelic
Composition
Srrtm1.2Jtc/Srrtm1.2Jtc
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srrtm1.2Jtc mutation (0 available); any Srr mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• cortical D-serine levels are approximately 10% of wild-type levels (J:158266)
• cortical D-serine levels are approximately 10% of wild-type levels (J:158266)
• decay kinetics of NMDAR mediated excitatory postsynaptic currents (EPSCs) are significantly slower (J:158266)
• perfusion of hippocampal containing coronal slices with D-serine (10 ÁM) induced a 93% increase compared to a 41.8% increase in wild-type (J:158266)
• decay kinetics of NMDAR mediated excitatory postsynaptic currents (EPSCs) are significantly slower (J:158266)
• perfusion of hippocampal containing coronal slices with D-serine (10 ÁM) induced a 93% increase compared to a 41.8% increase in wild-type (J:158266)
• a pairing paradigm fails to induce LTP at Schaffer collateral-CA1 pyramidal neuron synapse (J:158266)
• a pairing paradigm fails to induce LTP at Schaffer collateral-CA1 pyramidal neuron synapse (J:158266)

behavior/neurological
• females spend significantly less time in the center zone of the activity monitoring chambers during the first session (J:158266)
• females spend significantly less time in the center zone of the activity monitoring chambers during the first session (J:158266)
• male mice, but not female mice, do not spend significantly more time in the target quadrant of the water maze (J:158266)
• male mice, but not female mice, do not spend significantly more time in the target quadrant of the water maze (J:158266)
• in males but not females (J:158266)
• in males but not females (J:158266)
• in males but not females (J:158266)
• in males but not females (J:158266)

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:158266


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory