Mouse Genome Informatics
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• cortical D-serine levels are approximately 10% of wild-type levels
• decay kinetics of NMDAR mediated excitatory postsynaptic currents (EPSCs) are significantly slower
• perfusion of hippocampal containing coronal slices with D-serine (10 ÁM) induced a 93% increase compared to a 41.8% increase in wild-type
• a pairing paradigm fails to induce LTP at Schaffer collateral-CA1 pyramidal neuron synapse

• females spend significantly less time in the center zone of the activity monitoring chambers during the first session
• male mice, but not female mice, do not spend significantly more time in the target quadrant of the water maze
• in males but not females
• in males but not females

Mouse Models of Human Disease
Schizophrenia; SCZD 181500 J:158266