Phenotypes Associated with This Genotype

Genotype
MGI:4438893

• Allelic Composition: Adam10^tm1.1Dhc/Adam10^tm1.1Dhc; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:158127 )

• severely abrogated development of precursors to MZBs in the spleen

decreased transitional stage T2 B cell number ( J:158127 )

• decreased level of T2 B cells in the spleen

increased transitional stage T1 B cell number ( J:158127 )

• modestly increased percentage of T1 cells in the spleen compared with heterozygotes

• normal percentage of total B cells

absent marginal zone B cells ( J:158127 )

• absent marginal zone B cell (MZB) lineage in the spleen

• complete absence of MZBs surrounding the marginal sinus, labeled with the metallophilic macrophage marker 1 in the spleen

increased follicular B cell number ( J:158127 )

• increased level of follicular B cells in the spleen

immune system

abnormal B cell differentiation ( J:158127 )

• severely abrogated development of precursors to MZBs in the spleen

decreased transitional stage T2 B cell number ( J:158127 )

• decreased level of T2 B cells in the spleen

increased transitional stage T1 B cell number ( J:158127 )

• modestly increased percentage of T1 cells in the spleen compared with heterozygotes

• normal percentage of total B cells

absent marginal zone B cells ( J:158127 )

• absent marginal zone B cell (MZB) lineage in the spleen

• complete absence of MZBs surrounding the marginal sinus, labeled with the metallophilic macrophage marker 1 in the spleen

increased follicular B cell number ( J:158127 )

• increased level of follicular B cells in the spleen