Mouse Genome Informatics
cn
    Stk11tm1.1Rdp/Stk11tm1.1Rdp
Tg(Sprr2f-cre)1Dcas/0

involves: 129S6/SvEvTac * FVB/N
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• females display a marked increase in mortality; females begin to die at 17 weeks of age and all females are dead by 30 weeks
• death in most animals is infiltration of endometrial cancer into the urinary bladder
• 4 weeks of daily rapamycin treatment (started around 30 weeks) extended lifespan to 36 weeks+ compared to untreated control mutants

tumorigenesis
• endometrial carcinoma spreads to adjacent organs in older animals
• distant metastases (such as pulmonary or subcutaneous nodules) are observed infrequently
• female mortality results from invasive endometrial cancers
• tumor infiltration is progressive throughout the uteri resulting in diffuse uterine enlargement with increasing age
• uteri develop normally and are normal in size through onset of sexual maturity, but by 16 weeks of age there is significant uterine enlargement; in females surviving to 28 weeks, the average uterine weight is increased around 10 fold relative to controls
• by 12 weeks of age, diffuse infiltration of the myometrium is observed in most animals
• in older animals endometrial carcinoma spreads to adjacent organs, most significantly the ovary, cervix and bladder
• daily intraperitoneal rapamycin injections for 4 weeks (started around 30 weeks) slowed significantly slowed progression, resulting in 2.4 fold decrease in mean uterine weights; tumor burden is reduced and increased apoptotic cell death is detected in endometrial epithelial cells

reproductive system
• by 12 weeks of age, diffuse infiltration of the myometrium is observed in most animals
• uteri develop normally and are normal in size through onset of sexual maturity, but by 16 weeks of age there is significant uterine enlargement; in females surviving to 28 weeks, the average uterine weight is increased around 10 fold relative to controls
• tumor infiltration is progressive throughout the uteri resulting in diffuse uterine enlargement with increasing age
• by 16 weeks of age, there is significant uterine enlargement and in

renal/urinary system
• results from infiltration of endometrial carcinoma into the bladder
• uteri develop normally and are normal in size through onset of sexual maturity, but by 16 weeks of age there is significant uterine enlargement; in females surviving to 28 weeks, the average uterine weight is increased around 10 fold relative to controls
• tumor infiltration is progressive throughout the uteri resulting in diffuse uterine enlargement with increasing age
• urinary tract obstruction result from tumor infiltration into the bladder

digestive/alimentary system
• invasion through uterine wall results in peritonitis in some animals, contributing to morbity

immune system
• invasion through uterine wall results in peritonitis in some animals, contributing to morbity
• invasion through uterine wall results in sepsis in some animals, contributing to morbity

Mouse Models of Human Disease
OMIM IDRef(s)
Endometrial Cancer 608089 J:158190