Phenotypes Associated with This Genotype

Genotype
MGI:4438224

• Allelic Composition: Tg(ACTB-APP)1Colm/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal emotion/affect behavior ( J:157859 )

• old mice exhibit decreased immobility during a forced swim test compared with wild-type mice

behavioral despair ( J:157859 )

• young mice exhibit increased immobility during a forced swim test compared with wild-type mice

decreased startle reflex ( J:157859 )

• in young mice but not old mice

hyperactivity ( J:157859 )

• in young, but not old, mice exhibit increased activity in an open field test and entries in a Y-maze compared with wild-type mice

• at 9 and 22 months, mice exhibit slight hyperactivity compared with wild-type mice