Phenotypes for Vav2 MGI:4438044 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Vav2^tm1Kdf/Vav2^tm1Kdf
Genetic Background	B6.129S1-Vav2^tm1Kdf

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav2^tm1Kdf mutation (1 available); any Vav2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Progressive iridocorneal angle closures in Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat and Vav2^tm1Kdf/Vav2^tm1Kdf mice

vision/eye

abnormal iridocorneal angle ( J:158008 )

• between 4 and 16 weeks, some mice exhibit closed iridocorneal angles unlike wild-type mice

anterior iris synechia ( J:158008 )

• between 4 and 16 weeks, some mice exhibit peripheral anterior synechiae unlike wild-type mice

ocular hypertension ( J:158008 )

• at 7 weeks and increasing through 12 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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