Phenotypes for Igh Igk Trp53 Xrcc4 MGI:4437907 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Igh^tm2Cgn/Igh^tm2Cgn Igk^tm1Rsky/Igk^tm1Rsky Trp53^tm1Tyj/Trp53^tm1Tyj Xrcc4^tm1Fwa/Xrcc4^tm1Fwa
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (47 available)
Igk^tm1Rsky mutation (1 available); any Igk mutation (33 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (238 available)
Xrcc4^tm1Fwa mutation (0 available); any Xrcc4 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:126758 )

• class switching to IgG1 is 20% to 50% of wild-type

• class switching to IgG3 is 50% of wild-type

• IgH class switching is reduced compared to in wild-type B cells

cellular

increased cellular sensitivity to ionizing radiation induced cell death ( J:126758 )

• in cultured B cells

spontaneous chromosome breakage ( J:126758 )

• B cell stimulated with anti-CD40 and IL4 exhibit metaphase chromosome breaks unlike similarly treated wild-type cells

hematopoietic system