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Phenotypes Associated with This Genotype
Genotype
MGI:4437901
Allelic
Composition		 Lig4tm3.1Fwa/Lig4tm3.1Fwa
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm3.1Fwa mutation (0 available); any Lig4 mutation (46 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:157537 )
• mice exhibit similar class switch recombination defects observed in Lig4tm1Fwa Ightm2Cgn Igktm1Rsky Trp53tm1Tyj homozygotes

hematopoietic system
abnormal class switch recombination ( J:157537 )
• mice exhibit similar class switch recombination defects observed in Lig4tm1Fwa Ightm2Cgn Igktm1Rsky Trp53tm1Tyj homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory