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Phenotypes Associated with This Genotype
Genotype
MGI:4437856
Allelic
Composition		 Jag1tm1Jlew/Jag1tm1Jlew
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1Jlew mutation (0 available); any Jag1 mutation (78 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased angiogenesis ( J:157345 )
• postnatal tamoxifen treatment from P1-P3 results in decreased angiogenesis in the retina assessed at P6; significantly decreased vascular branching and endothelial cell coverage at P6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory