Phenotypes Associated with This Genotype

Genotype
MGI:4437462

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Trp53^tm1Brn/Trp53⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased thyroid carcinoma incidence ( J:86077 , J:157319 )

• medullary thyroid carcinomas in 2 of 13 mice treated with a cre-expressing adenovirus (J:86077)

• following treatment with cre-expressing adenovirus, 2 of 13 mice exhibit medullary thyroid carcinoma unlike wild-type mice (J:157319)

increased lung tumor incidence ( J:157319 )

• mice treated with cre-expressing adenovirus median tumor-free survival is 475 days

increased lung adenocarcinoma incidence ( J:86077 , J:157319 )

• in some mice treated with a cre-expressing adenovirus (J:86077)

• in some mice following treatment with cre-expressing adenovirus (J:157319)

increased lung small cell carcinoma incidence ( J:86077 , J:157319 )

• large in 5 of 13 mice treated with a cre-expressing adenovirus (J:86077)

• in some mice following treatment with cre-expressing adenovirus (J:157319)

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:86077 , J:157319 )

• medullary thyroid carcinomas in 2 of 13 mice treated with a cre-expressing adenovirus (J:86077)

• following treatment with cre-expressing adenovirus, 2 of 13 mice exhibit medullary thyroid carcinoma unlike wild-type mice (J:157319)

respiratory system

increased lung tumor incidence ( J:157319 )

• mice treated with cre-expressing adenovirus median tumor-free survival is 475 days

increased lung adenocarcinoma incidence ( J:86077 , J:157319 )

• in some mice treated with a cre-expressing adenovirus (J:86077)

• in some mice following treatment with cre-expressing adenovirus (J:157319)

increased lung small cell carcinoma incidence ( J:86077 , J:157319 )

• large in 5 of 13 mice treated with a cre-expressing adenovirus (J:86077)

• in some mice following treatment with cre-expressing adenovirus (J:157319)