Phenotypes for Chrm1 Emx1 MGI:4437232 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Chrm1^tm2.1Stl/Chrm1^tm2.1Stl Emx1^{tm1.1(cre)Ito}/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1^tm2.1Stl mutation (0 available); any Chrm1 mutation (27 available)
Emx1^{tm1.1(cre)Ito} mutation (1 available); any Emx1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal excitatory postsynaptic currents ( J:156540 )

• baseline excitatory postsynaptic currents from hippocampal slices are higher than in wild-type

abnormal miniature excitatory postsynaptic currents ( J:156540 )

• the frequency of events is significantly higher in miniature excitatory postsynaptic currents (minis) from CA1 pyramidal neurons

abnormal long-term depression ( J:156540 )

• (S)-3,5-dihydroxyphenylglycine hydrate (DHPG), an mGluR agonist, fails to produce long-term depression in hippocampal slices

decreased paired-pulse facilitation ( J:156540 )

• decrease in degree of facilitation of the second response in a paired-pulse

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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