Phenotypes for En1 Fgf8 MGI:4437223 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^{tm7(cre/ESR1)Alj} mutation (1 available); any En1 mutation (34 available)
Fgf8^tm1.3Mrt mutation (1 available); any Fgf8 mutation (25 available)
Fgf8^tm1.4Mrt mutation (0 available); any Fgf8 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Raphe nucleus morphology ( J:156717 )

• a reduction of serotonergic neurons in raphe nuclei

abnormal midbrain morphology ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

abnormal substantia nigra morphology ( J:156717 )

• depletion of dopaminergic neurons at E18.5

small cerebellum ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

decreased dopaminergic neuron number ( J:156717 )

• at E18.5 in the substantia nigra and ventral tegmental area

abnormal serotonergic neuron morphology ( J:156717 )

• at E18.5 a reduction of serotonergic neurons in the raphe nucleus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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