Phenotypes Associated with This Genotype

Genotype
MGI:4437222

• Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0; Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:156717 )

• die at birth

nervous system

abnormal neural tube morphology ( J:156717 )

• a significant increase in the number of dead cells in the mesencephalon and to a less extent in rhombomere of the neural tube of embryos at the 13-somite stage

abnormal rhombomere morphology ( J:156717 )

• a significant increase in the number of dead cells in rhombomere of the neural tube of embryos at the 13-somite stage

abnormal Raphe nucleus morphology ( J:156717 )

• a reduction of serotonergic neurons in raphe nuclei

abnormal midbrain morphology ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

• a significant increase in the number of dead cells in the mesencephalon at the 13-somite stage

abnormal substantia nigra morphology ( J:156717 )

• depletion of dopaminergic neurons at E18.5

small cerebellum ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

decreased dopaminergic neuron number ( J:156717 )

• at E18.5 in the substantia nigra and ventral tegmental area

abnormal serotonergic neuron morphology ( J:156717 )

• at E18.5 a reduction of serotonergic neurons in the raphe nucleus

embryo

abnormal neural tube morphology ( J:156717 )

• a significant increase in the number of dead cells in the mesencephalon and to a less extent in rhombomere of the neural tube of embryos at the 13-somite stage

abnormal rhombomere morphology ( J:156717 )

• a significant increase in the number of dead cells in rhombomere of the neural tube of embryos at the 13-somite stage