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Phenotypes Associated with This Genotype
Genotype
MGI:4437062
Allelic
Composition
Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (9 available); any Cd19 mutation (36 available)
Del(14Trim13-Dleu2)4Rdf mutation (0 available); any Del(14Trim13-Dleu2)4Rdf mutation (0 available)
Is(14)1Rdf mutation (0 available); any Is(14)1Rdf mutation (0 available)
Is(14)2Rdf mutation (1 available); any Is(14)2Rdf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• monoclonal B cell lymphocytosis in some mice at 15 - 18 months of age
• at 15-18 months increased clonal population in the peripheral blood
• expansion or accumulation of small lymphocytes, with a pattern similar small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL) and with characteristic 'smudge' cells in some mice

immune system
• monoclonal B cell lymphocytosis in some mice at 15 - 18 months of age
• at 15-18 months increased clonal population in the peripheral blood
• expansion or accumulation of small lymphocytes, with a pattern similar small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL) and with characteristic 'smudge' cells in some mice

neoplasm
• a fraction of mice have histological features of small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL)
• some of the CD5 negative tumors showed a mature B cell phenotype histologically reminiscent of human diffuse large B cell lymphoma, non-Hodgkin lymphoma
• a minority of CD5 negative tumors showed plasmacytic features similar to lymphoplasmacytic lymphoma


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory