Phenotypes Associated with This Genotype

Genotype
MGI:4436884

• Allelic Composition: Ctsb^tm1Jde/Ctsb^tm1Jde; Ctsz^tm1Thre/Ctsz^tm1Thre; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: FVB.129P2-Ctsz^tm1Thre Ctsb^tm1Jde Tg(MMTV-PyVT)634Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:157541 )

decreased metastatic potential ( J:157541 )

• 70% fewer lung metastases compared with Tg(MMTV-PyVT)634Mul/0 mice

• 80% smaller average metastasis size

• form significantly less and shorter invasive strands in vitro

abnormal tumor morphology ( J:157541 )

• 28% of the tumors are poorly differentiated, compared with 75% of both Tg(MMTV-PyVT)634Mul/0 and Tg(MMTV-PyVT)634Mul/0; Ctsz^tm1Thre/Ctsz^tm1Thre tumors

• more of the tumors are well differentiated or moderately differentiated

decreased tumor growth/size ( J:157541 )

• with nonpalpable and small tumors even at 14 weeks of age

• tumor weight is reduced to 45% compared with Tg(MMTV-PyVT)634Mul/0 mice

increased tumor latency ( J:157541 )

• develop an average of five palpable tumors 7.5 days later than the Tg(MMTV-PyVT)634Mul/0 mice

cellular

decreased apoptosis ( J:157541 )

• decreased TUNEL-positive cells compared with Ctsb^tm1Jde/Ctsb^tm1Jde;Tg(MMTV-PyVT)634Mul/0 mice

integument

increased mammary gland tumor incidence ( J:157541 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:157541 )