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Phenotypes Associated with This Genotype
Genotype
MGI:4436871
Allelic
Composition		 Cd86tm1Shr/Cd86tm1Shr
Marchf1tm1.1Sish/Marchf1tm1.1Sish
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd86tm1Shr mutation (9 available); any Cd86 mutation (41 available)
Marchf1tm1.1Sish mutation (1 available); any Marchf1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-12 secretion ( J:157516 )
• in dendritic cells following LPS or anti-CD40 antibody stimulation
decreased tumor necrosis factor secretion ( J:157516 )
• in dendritic cells following LPS or anti-CD40 antibody stimulation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory