Mouse Genome Informatics
hm
    Npc1m1N/Npc1m1N
B6.C-Npc1m1N
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

hematopoietic system

homeostasis/metabolism
• Background Sensitivity: increased lipid accumulation in P49 liver tissue as compared to BALB/c background
• Background Sensitivity: lipids include: ceramides, monohexosyceramides, sphingomyelins, sphingoid bases, gangiosides, free cholesterol, 24(S)-hydroxycholesterol, 4beta-hydroxy cholesterol and cholesterol ester
• mice exhibit an increase in unestrified cholesterol in the cerebellum compared with wild-type mice
• Background Sensitivity: increased accumulation in P49 liver tissue as compared to BALB/c background
• Background Sensitivity: increased accumulation in P49 liver tissue as compared to BALB/c background
• Background Sensitivity: increased accumulation in P49 liver and brain tissue as compared to BALB/c background

cellular
• mice exhibit proliferation of foamy cells in the liver unlike wild-type mice

immune system

liver/biliary system
• Background Sensitivity: increased accumulation in P49 liver tissue as compared to BALB/c background

Mouse Models of Human Disease
OMIM IDRef(s)
Niemann-Pick Disease, Type C1; NPC1 257220 J:157113