Mouse Genome Informatics
ht
    Npc1m1N/Npc1tm1.2Apl
B6.Cg-Npc1m1N/Npc1tm1.2Apl
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice die around 49 days of age
• no mice survive longer than 9 weeks

nervous system

behavior/neurological
• on a rotarod

growth/size
• at weaning
• at 7 weeks of age

homeostasis/metabolism
• mice exhibit an increase in unestrified cholesterol in the cerebellum compared with wild-type mice

cellular
• mice exhibit proliferation of foamy cells in the liver unlike wild-type mice

immune system

hematopoietic system

Mouse Models of Human Disease
OMIM IDRef(s)
Niemann-Pick Disease, Type C1; NPC1 257220 J:157113