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Phenotypes Associated with This Genotype
Genotype
MGI:4431014
Allelic
Composition		 Prlrtm1Cnp/Prlrtm1Cnp
Tg(C3-1-TAg)cJeg/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (41 available)
Tg(C3-1-TAg)cJeg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate intraepithelial neoplasia incidence ( J:84352 )
• mice exhibit a decrease in prostate intraepithelial neoplasia (PIN) in the ventral lobe compared with Tg(C3-1-TAg)cJeg mice
• however, PIN development in the dorsal lobe is the same as in Tg(C3-1-TAg)cJeg mice and mice do not develop prostate tumors

endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:84352 )
• mice exhibit a decrease in prostate intraepithelial neoplasia (PIN) in the ventral lobe compared with Tg(C3-1-TAg)cJeg mice
• however, PIN development in the dorsal lobe is the same as in Tg(C3-1-TAg)cJeg mice and mice do not develop prostate tumors

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:84352 )
• mice exhibit a decrease in prostate intraepithelial neoplasia (PIN) in the ventral lobe compared with Tg(C3-1-TAg)cJeg mice
• however, PIN development in the dorsal lobe is the same as in Tg(C3-1-TAg)cJeg mice and mice do not develop prostate tumors

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory