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Phenotypes Associated with This Genotype
Genotype
MGI:4430745
Allelic
Composition		 Trp53tm1Brd/Trp53tm1Brd
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)1Cwi mutation (3 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (236 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:157041 )
• all die of thymic lymphomas by 50 weeks of age

neoplasm
increased T cell derived lymphoma incidence ( J:157041 )
• in all mice by 50 weeks of age

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:157041 )
• in all mice by 50 weeks of age

hematopoietic system
increased T cell derived lymphoma incidence ( J:157041 )
• in all mice by 50 weeks of age

immune system
increased T cell derived lymphoma incidence ( J:157041 )
• in all mice by 50 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory