Phenotypes Associated with This Genotype

Genotype
MGI:4430569

• Allelic Composition: Ccr7^tm1Rfor/Ccr7^tm1Rfor; Tg(DO11.10)10Dlo/?
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:123482 )

abnormal regulatory T cell physiology ( J:123482 )

• significantly reduced ability of T regulatory cells to enter mesenteric and peripheral lymph nodes

• more moderately reduced ability of T regulatory cells to enter Peyer's patches and the gut

• greater ability to migrate into the liver

• failure of T regulatory cells to localize to T cell zones of lymph nodes

• reduced movement of T regulatory cells away from peripheral sites of inflammation

cellular

abnormal cell migration ( J:123482 )

abnormal leukocyte migration ( J:123482 )

hematopoietic system

abnormal leukocyte migration ( J:123482 )

abnormal regulatory T cell physiology ( J:123482 )

• significantly reduced ability of T regulatory cells to enter mesenteric and peripheral lymph nodes

• more moderately reduced ability of T regulatory cells to enter Peyer's patches and the gut

• greater ability to migrate into the liver

• failure of T regulatory cells to localize to T cell zones of lymph nodes

• reduced movement of T regulatory cells away from peripheral sites of inflammation