Phenotypes Associated with This Genotype

Genotype
MGI:4430068

• Allelic Composition: Tg(KRT5-TGFB1)F2020Xjw/0
• Genetic Background: involves: C57BL/6 * DBA/2 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

cutaneous mastocytosis ( J:90118 )

• increased mast cell number in the dermis

abnormal Langerhans cell morphology ( J:90118 )

• more Langerhans cells are found in the dermis compared to in wild-type mice

decreased Langerhans cell number ( J:90118 )

• fewer Langerhans cells are found in the epidermis compared to in wild-type mice

abnormal Langerhans cell physiology ( J:90118 )

• Langerhans cells migrate from the dermis to the epidermis

skin inflammation ( J:90118 )

• beginning at 1 month of age, mice develop skin inflammation unlike wild-type mice

• at 2 months, ear-tagged develop focal lesions unlike similarly treated wild-type mice

• the skin contains scattered mononuclear cells and subcorneal microabscesses with mixed mononuclear cells and neutrophils unlike wild-type skin

• inflammatory infiltrate into the skin includes neutrophils, T lymphocytes, and macrophages

cardiovascular system

increased angiogenesis ( J:90118 )

• in the skin as early as P7

pathological neovascularization ( J:90118 )

• dermis exhibits neovascularization, enlarged capillary cavities, and extravasated erythrocytes unlike in wild-type mice

hematopoietic system

cutaneous mastocytosis ( J:90118 )

• increased mast cell number in the dermis

abnormal Langerhans cell morphology ( J:90118 )

• more Langerhans cells are found in the dermis compared to in wild-type mice

decreased Langerhans cell number ( J:90118 )

• fewer Langerhans cells are found in the epidermis compared to in wild-type mice

integument

abnormal dermal layer morphology ( J:90118 )

• dermis exhibits neovascularization, enlarged capillary cavities, and extravasated erythrocytes unlike in wild-type mice

hyperkeratosis ( J:90118 )

parakeratosis ( J:90118 )

abnormal epidermis stratum granulosum morphology ( J:90118 )

• keratinocytes, especially granular cells, exhibit an increase in lipid vesicles compared to in wild-type mice

thin epidermis stratum granulosum ( J:90118 )

acanthosis ( J:90118 )

abnormal epidermis suprabasal layer morphology ( J:90118 )

• proliferating cells are expanded in the suprabasal epidermis compared to in wild-type mice

abnormal keratinocyte morphology ( J:90118 )

• keratinocytes, especially granular cells, exhibit an increase in lipid vesicles compared to in wild-type mice

reddish skin ( J:90118 )

• by 3 months of age, mice exhibit scaly focal erythematous plaques unlike wild-type mice

scaly skin ( J:90118 )

• by 3 months of age, mice exhibit scaly focal erythematous plaques unlike wild-type mice

skin lesions ( J:90118 )

• by 3 months of age, mice exhibit scaly focal erythematous plaques unlike wild-type mice

psoriasis ( J:90118 )

• as skin inflammation progresses the entire skin becomes scaly and erythematous similar to in human psoriatic erytheroderma

abnormal skin physiology ( J:90118 )

• at 3 months, mice exhibit hyperproliferation and reduced differentiation compared to in wild-type mice

decreased keratinocyte proliferation ( J:90118 )

• in vitro keratinocytes only reach 40% confluency compared with wild-type mice

skin inflammation ( J:90118 )

• beginning at 1 month of age, mice develop skin inflammation unlike wild-type mice

• at 2 months, ear-tagged develop focal lesions unlike similarly treated wild-type mice

• the skin contains scattered mononuclear cells and subcorneal microabscesses with mixed mononuclear cells and neutrophils unlike wild-type skin

• inflammatory infiltrate into the skin includes neutrophils, T lymphocytes, and macrophages

cellular

decreased keratinocyte proliferation ( J:90118 )

• in vitro keratinocytes only reach 40% confluency compared with wild-type mice

abnormal basement membrane morphology ( J:90118 )

• skin exhibits basement membrane degeneration unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:90118