Phenotypes Associated with This Genotype

Genotype
MGI:4429630

• Allelic Composition: Hr^hr/Hr^hr; Msh2^tm1Htr/Msh2^tm1Htr
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by ionizing radiation ( J:79734 )

• 20% of mice die 15 weeks after UVB-irradiation unlike similarly treated wild-type mice

premature death ( J:79734 )

• 20% of mice die of lymphomas by 20 weeks of age

neoplasm

increased incidence of tumors by UV-induction ( J:79734 )

• 15 weeks after UVB-irradiation, mice develop lymphomas unlike similarly treated wild-type mice

• 18 weeks after UVB-irradiation mice develop skin tumors compared with 23 weeks for similarly treated wild-type mice

• UVB-irradiated mice do not remain tumor free as long as similarly treated wild-type mice

increased skin tumor incidence ( J:79734 )

• by 52 weeks, 81% of mice develop skin tumors

• 18 weeks after UVB-irradiation mice develop skin tumors compared with 23 weeks for similarly treated wild-type mice

increased skin papilloma incidence ( J:79734 )

• 23% of spontaneous skin tumors are papillomas

increased skin squamous cell carcinoma incidence ( J:79734 )

• 77% of spontaneous skin tumors are squamous cell carcinomas

increased lymphoma incidence ( J:79734 )

• 20% of mice die of lymphomas by 20 weeks of age

• 15 weeks after UVB-irradiation, mice develop lymphomas unlike similarly treated wild-type mice

integument

increased skin tumor incidence ( J:79734 )

• by 52 weeks, 81% of mice develop skin tumors

• 18 weeks after UVB-irradiation mice develop skin tumors compared with 23 weeks for similarly treated wild-type mice

increased skin papilloma incidence ( J:79734 )

• 23% of spontaneous skin tumors are papillomas

increased skin squamous cell carcinoma incidence ( J:79734 )

• 77% of spontaneous skin tumors are squamous cell carcinomas

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:79734 )

• 20% of mice die 15 weeks after UVB-irradiation unlike similarly treated wild-type mice

increased incidence of tumors by UV-induction ( J:79734 )

• 15 weeks after UVB-irradiation, mice develop lymphomas unlike similarly treated wild-type mice

• 18 weeks after UVB-irradiation mice develop skin tumors compared with 23 weeks for similarly treated wild-type mice

• UVB-irradiated mice do not remain tumor free as long as similarly treated wild-type mice