Phenotypes Associated with This Genotype

Genotype
MGI:4429607

• Allelic Composition: Msh2^tm1Htr/Msh2⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:45433 )

• mice die within 100 weeks

neoplasm

increased tumor incidence ( J:45433 )

• mice develop more tumors than wild-type mice including lung, liver, mammary gland, skin, uterus, hemangiosarcoma, Schwann cell, teratocarcinoma, osteosarcoma, adrenal gland, and bladder tumors

increased mammary gland tumor incidence ( J:45433 )

increased skin tumor incidence ( J:45433 )

increased liver tumor incidence ( J:45433 )

increased hemangiosarcoma incidence ( J:45433 )

increased osteosarcoma incidence ( J:45433 )

increased uterus tumor incidence ( J:45433 )

♀

increased lung tumor incidence ( J:45433 )

integument

increased mammary gland tumor incidence ( J:45433 )

increased skin tumor incidence ( J:45433 )

liver/biliary system

increased liver tumor incidence ( J:45433 )

respiratory system

increased lung tumor incidence ( J:45433 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:45433 )

reproductive system

increased uterus tumor incidence ( J:45433 )

♀

skeleton

increased osteosarcoma incidence ( J:45433 )