Mouse Genome Informatics
hm
    Msh2tm1Htr/Msh2tm1Htr
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• two-third of mice die by 19.5 weeks
• Background Sensitivity: mice on a pure 129P2/OlaHsd background die sooner than those on a mixed 129P2/OlaHsd and FVB background

immune system
N
• somatic hypermutation rates in memory B cells are normal (J:47993)
• LPS-stimulated blasting B cells exhibit a 7-fold reduction in switching to IgG3 compared with similarly treated wild-type mice
• however, IgM response to LPS treatment is normal
• mice exhibit a 61% reduction in total mutation frequency in germinal center B cell compared with wild-type mice
• following NP-ficcoll or LPS plus IL4 stimulation
• following NP-ficcoll or LPS stimulation
• LPS-stimulated blasting B cells exhibit a 7-fold reduction in switching to IgG3 compared with similarly treated wild-type mice
• however, the proportion of B cells that blasted in response to LPS is normal

tumorigenesis
• mice that survive beyond 19.5 weeks exhibit a multitude of tumor types (lymphoid, erythroid, intestine, skin, sebaceous gland, brain, intestine, and hereditary nonpolyposis colorectal cancer)
• in mice that survive beyond 19.5 weeks
• 80% of mice that die prior to 19.5 weeks of age present with a lymphoid tumor, mostly of T cell origin
• all mice that survive beyond 30 weeks develop HNPCC (hereditary nonpolyposis colorectal cancer)
• in 13% of mice that survive beyond 19.5 weeks

hematopoietic system
• LPS-stimulated blasting B cells exhibit a 7-fold reduction in switching to IgG3 compared with similarly treated wild-type mice
• however, IgM response to LPS treatment is normal
• mice exhibit a 61% reduction in total mutation frequency in germinal center B cell compared with wild-type mice
• following NP-ficcoll or LPS plus IL4 stimulation
• following NP-ficcoll or LPS stimulation

integument
• in mice that survive beyond 19.5 weeks

Mouse Models of Human Disease
OMIM IDRef(s)
Lynch Syndrome I 120435 J:45433