Phenotypes for Vav1 Vav2 MGI:4429590 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Vav1^tm1Tyb/Vav1^tm1Tyb Vav2^tm1Kdf/Vav2^tm1Kdf
Genetic Background	involves: 129S1/Sv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1^tm1Tyb mutation (2 available); any Vav1 mutation (58 available)
Vav2^tm1Kdf mutation (1 available); any Vav2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell proliferation ( J:86654 )

• B cells show reduced proliferation in response to Ig receptor stimulation

decreased T cell proliferation ( J:86654 )

• ability of T cells to generate blasts when stimulated is reduced by 3- to 4-fold, indicating a proliferation defect

decreased mature B cell number ( J:86654 )

• 2- to 3-fold reduction in mature IgM^loIgD^hi B cells

decreased T cell number ( J:86654 )

• few peripheral T cells

decreased thymocyte number ( J:86654 )

decreased double-negative T cell number ( J:86654 )

decreased double-positive T cell number ( J:86654 )

decreased single-positive T cell number ( J:86654 )

decreased interferon-gamma secretion ( J:86654 )

• production of IFN-gamma by T cells in response to TCR stimulation is reduced

decreased interleukin-2 secretion ( J:86654 )

• production of IL-2 by T cells in response to TCR stimulation is reduced

hematopoietic system

decreased B cell proliferation ( J:86654 )

• B cells show reduced proliferation in response to Ig receptor stimulation

decreased T cell proliferation ( J:86654 )

• ability of T cells to generate blasts when stimulated is reduced by 3- to 4-fold, indicating a proliferation defect

decreased mature B cell number ( J:86654 )

• 2- to 3-fold reduction in mature IgM^loIgD^hi B cells

decreased T cell number ( J:86654 )

• few peripheral T cells

decreased thymocyte number ( J:86654 )

decreased double-negative T cell number ( J:86654 )

decreased double-positive T cell number ( J:86654 )

decreased single-positive T cell number ( J:86654 )

endocrine/exocrine glands

decreased thymocyte number ( J:86654 )

cellular

decreased B cell proliferation ( J:86654 )

• B cells show reduced proliferation in response to Ig receptor stimulation

decreased T cell proliferation ( J:86654 )

• ability of T cells to generate blasts when stimulated is reduced by 3- to 4-fold, indicating a proliferation defect

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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